BOUTARFA Mariem Wissal, CHIKH Dhouha2025-09-212025-09-212025-06-09http//localhost:8080/jspui/handle/123456789/13128This study investigates the biological properties of the hydroethanolic extract of Citrullus colocynthis, focusing on its antioxidant, antidiabetic, and insecticidal activities against mosquito species. The yield of the hydro-ethanolic extract of the fruit of Citrullus colocynthis was 19.21%. Antioxidant assays showed moderate free radical scavenging ability. The antidiabetic activity was confirmed through inhibition of α-glucosidase enzyme. Additionally, the extract exhibited significant insecticidal potential, highlighting its possible use in pharmaceutical and entomological fields.enCitrullus colocynthis, hydroethanolic extract, antioxidant activity, antidiabetic activity, insecticidal effect, mosquitoes.Thesis